Brexit may have big implications for US companies. Many are wondering what it will mean for their business—now and down the road. Boards need to know what to ask management as companies navigate Brexit’s near- and long-term impact. The immediate reaction from the UK’s decision to leave the European Union—surprise, confusion, and stock market volatility—has tempered somewhat, but many companies remain concerned about the longer-term implications on their business and strategy. US companies that are engaged in UK or EU financial or stock markets or operate in, sell to, or buy from the UK or EU are likely to experience some effects. Their boards of directors should ask the right questions to help companies prepare to steer through these uncertain waters. So what should boards be asking management?