The Leave campaign’s victory, with a margin of 3.8 percentage points, has likely ushered in a protracted phase of uncertainty for the UK, EU, and global economies. A systemic shock cutting across industries and borders, Brexit poses significant strategic challenges for business leaders as they navigate the fallout. Judging by our interactions with CEOs around the world to date, some of their burning questions are: What are the elements of uncertainty created by Brexit? How can leaders develop a specific view of the industry- and firm-level implications? What are the first-response imperatives for corporate leaders? What structural changes to the business environment are triggered by Brexit, and how do we adapt to them?